Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, 18th Kilometer Farahabad Road, 48175861 Sari, Mazandaran Province, Iran.
World J Surg. 2013 Jan;37(1):233-8. doi: 10.1007/s00268-012-1805-8.
The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy.
A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospective, double-blind, randomized, controlled trial and were randomly divided into two groups (24 in each group), receiving either sucralfate ointment or placebo immediately after surgery and then every 12 h for 14 days. The primary outcome measure was pain intensity measured by a visual analogue scale at different time points after hemorrhoidectomy.
The sucralfate group had significantly less pain than the placebo group at 24th h and the 48th h after hemorrhoidectomy (4 ± 1.14 vs 5.08 ± 0.97; P = 0.001 and 3 ± 0.72 vs 4.41 ± 0.8; P < 0.001, respectively), and they consumed lower amounts of analgesics at the same time intervals (12.50 ± 16.48 vs 21.87 ± 15.30 mg of pethidine; P = 0.047 and 152 ± 23 vs 172 ± 29 mg of diclofenac; P = 0.009, respectively). The same trend continued until the end of the trial.
Sucralfate ointment reduced the acute postoperative pain after hemorrhoidectomy.
本研究旨在评估 10%蔗糖铁软膏在减轻痔切除术后急性疼痛中的疗效。
本前瞻性、双盲、随机、对照试验纳入 48 例年龄在 20 至 70 岁之间的行痔切除术患者（24 名男性和 24 名女性），并将其随机分为两组（每组 24 例），术后立即给予蔗糖铁软膏或安慰剂，随后每 12 小时使用一次，共 14 天。主要观察指标为痔切除术后不同时间点的视觉模拟评分法（VAS）疼痛强度。
与安慰剂组相比，蔗糖铁组在术后 24 小时和 48 小时的疼痛明显减轻（4 ± 1.14 对 5.08 ± 0.97；P = 0.001 和 3 ± 0.72 对 4.41 ± 0.8；P < 0.001），且在相同时间间隔内使用的镇痛药剂量较低（12.50 ± 16.48 对 21.87 ± 15.30 mg 哌替啶；P = 0.047 和 152 ± 23 对 172 ± 29 mg 双氯芬酸；P = 0.009）。这种趋势一直持续到试验结束。
蔗糖铁软膏可减轻痔切除术后的急性疼痛。
