Department of Occupational and Environmental Health, St Michael's Hospital, Toronto, Ontario, Canada.
Dermatitis. 2012 Sep-Oct;23(5):227-30. doi: 10.1097/DER.0b013e318262cadb.
Tylosin is a broad-spectrum macrolide antibiotic that is restricted to veterinary use. Allergic contact dermatitis (ACD) caused by tylosin has been reported in the literature from the farming industry and veterinary medicine. It is also reported as the most common antibiotic to cause ACD in the previously mentioned occupational settings. We present 2 cases of airborne ACD from tylosin among veterinary pharmaceutical compounding technicians. To our knowledge, only one other case of patch test-confirmed tylosin ACD has been reported in the manufacturing setting. Based on our results, cross-sensitization to other clinically relevant macrolides does not appear to be a concern. Our cases highlight the importance of patch testing among pharmaceutical compounders where the incidence of an airborne contact may be greater, given that the exposure is to the powdered form of potential allergens.
泰乐菌素是一种广谱大环内酯类抗生素，仅限于兽医使用。文献中有报道称，泰乐菌素会引起过敏性接触性皮炎（ACD），这种情况发生在农业和兽医领域。据报道，它也是上述职业环境中最常见的引起 ACD 的抗生素。我们报告了 2 例兽医制药配制技术人员因泰乐菌素而发生的空气传播 ACD。据我们所知，仅在制造环境中报告过一例经斑贴试验证实的泰乐菌素 ACD。基于我们的结果，对其他临床相关大环内酯类药物的交叉致敏似乎不是问题。我们的病例强调了在制药配制人员中进行斑贴试验的重要性，因为他们可能会接触到潜在过敏原的粉末形式，因此空气传播接触的发生率可能更高。
