脑卒中患者活体脑谷胱甘肽测量的初步研究结果。
Pilot results of in vivo brain glutathione measurements in stroke patients.
机构信息
Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Cereb Blood Flow Metab. 2012 Dec;32(12):2118-21. doi: 10.1038/jcbfm.2012.127. Epub 2012 Sep 26.
Abstract
Measurement of glutathione concentration for the study of redox status in subjects with neurological disease has been limited to peripheral markers. We recruited 19 subjects with large strokes. Using magnetic resonance spectroscopy we measured brain glutathione concentration in the stroke region and in healthy tissue to calculate a glutathione-ratio. Elevated glutathione-ratio was observed in subacute (<72 hours) subjects without hemorrhagic transformation (mean=1.19, P=0.03, n=6). No trend was seen when all subjects were considered (n=19, 3 to 754 hours, range=0.45 to 1.41). This technique can detect glutathione changes because of disease, and may be valuable in clinical trials of stroke and other neurological diseases.
摘要
测定神经疾病患者氧化还原状态的谷胱甘肽浓度的研究一直局限于外周标志物。我们招募了 19 名大面积中风患者。我们使用磁共振波谱法测量了中风区域和健康组织中的脑谷胱甘肽浓度，以计算谷胱甘肽比。未发生出血性转化的亚急性期（<72 小时）患者（n=6）观察到谷胱甘肽比升高（平均值=1.19，P=0.03）。当考虑所有患者时（n=19，3 至 754 小时，范围=0.45 至 1.41），未见趋势。该技术可以检测到因疾病引起的谷胱甘肽变化，可能对中风和其他神经疾病的临床试验有价值。
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