Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Osteoporos Int. 2013 May;24(5):1623-36. doi: 10.1007/s00198-012-2144-1. Epub 2012 Sep 26.
The aim of this randomized controlled trial was to determine whether whole body vibration (WBV) therapy was effective for treating osteopenia in adolescent idiopathic scoliosis (AIS) patients. Results showed that WBV was effective for improving areal bone mineral density (aBMD) at the femoral neck of the dominant side and lumbar spine BMC in AIS subjects.
AIS is associated with osteopenia. Although WBV was shown to have skeletal anabolic effects in animal studies, its effect on AIS subjects remained unknown. The objective of this study was to determine whether WBV could improve bone mineral density (BMD) and bone quality for osteopenia in AIS subjects.
This was a randomized, controlled trial recruiting 149 AIS girls between 15 and 25 years old and with bone mineral density (BMD) Z-scores <-1. They were randomly assigned to the Treatment or Control groups. The Treatment group (n = 61) stood on a low-magnitude high-frequency WBV platform 20 min/day, 5 days/week for 12 months. The Control group (n = 63) received observation alone. Bone measurement was done at baseline and at 12 months: (1) aBMD and BMC at femoral necks and lumbar spine using dual-energy X-ray absorptiometry (DXA) and (2) bone quality including bone morphometry, volumetric BMD (vBMD), and trabecular bone microarchitecture using high-resolution peripheral quantitative computed tomography (HR-pQCT) for nondominant distal radius and bilateral distal tibiae.
The Treatment group had numerically greater increases in all DXA parameters with a statistically significant difference being detected for the absolute and percentage increases in femoral neck aBMD at the dominant leg (0.015 (SD = 0.031)g/cm(2), 2.15 (SD = 4.32)%) and the absolute increase in lumbar spine BMC (1.17 (SD = 2.05)g) in the Treatment group as compared with the Control group (0.00084 (SD = 0.026)g/cm(2), 0.13 (SD = 3.62)% and 0.47 (SD = 1.88)g, respectively). WBV had no significant effect for other bone quality parameters.
WBV was effective for improving aBMD at the femoral neck of the dominant side and lumbar spine BMC in AIS subjects.
本随机对照试验旨在确定全身振动（WBV）治疗是否对治疗特发性脊柱侧凸（AIS）青少年的骨质疏松症有效。结果表明，WBV 可有效改善 AIS 患者优势侧股骨颈和腰椎骨矿物质含量（BMC）的面积骨密度（aBMD）。
AIS 与骨质疏松症有关。虽然动物研究表明 WBV 具有骨骼合成代谢作用，但对 AIS 患者的影响尚不清楚。本研究的目的是确定 WBV 是否可以改善 AIS 患者的骨密度（BMD）和骨质量，以治疗骨质疏松症。
这是一项招募了 149 名 15 至 25 岁且骨密度（BMD）Z 评分<-1 的 AIS 女孩的随机对照试验。她们被随机分配到治疗组或对照组。治疗组（n=61）每天在低幅度高频 WBV 平台上站立 20 分钟，每周 5 天，共 12 个月。对照组（n=63）仅接受观察。在基线和 12 个月时进行骨骼测量：（1）使用双能 X 射线吸收法（DXA）测量股骨颈和腰椎的 aBMD 和 BMC；（2）使用高分辨率外周定量计算机断层扫描（HR-pQCT）测量非优势侧远端桡骨和双侧胫骨远端的骨质量，包括骨形态计量学、体积 BMD（vBMD）和小梁骨微结构。
治疗组的所有 DXA 参数均有数值上的增加，其中在优势侧股骨颈 aBMD 的绝对和百分比增加方面，治疗组具有统计学意义（0.015（SD=0.031）g/cm2，2.15（SD=4.32）%）和腰椎骨 BMC 的绝对增加（1.17（SD=2.05）g）与对照组相比，差异有统计学意义（0.00084（SD=0.026）g/cm2，0.13（SD=3.62）%和 0.47（SD=1.88）g，分别）。WBV 对其他骨质量参数没有显著影响。
WBV 可有效改善 AIS 患者优势侧股骨颈和腰椎骨 BMC 的 aBMD。
