1000名沙特男性中用于检测前列腺癌的筛查测试的价值。
The value of screening tests for detection of prostate cancer in 1000 saudi men.
作者信息
Kamal Baher A
机构信息
Department of Urology, College of Medicine, King Faisal University, Dammam, Saudi Arabia.
出版信息
J Family Community Med. 2004 Sep;11(3):97-102.
OBJECTIVES
Predicting the value of screening tests in the detection of prostate cancer in Saudi men.
METHODS
The study was conducted in King Fahd Hospital of the University, Al-Khobar. Total, free and percent free serum prostate specific antigen (PSA) were measured in Saudi men above the age of 45 years. Transrectal ultrasonography (TRUS) and needle biopsy were performed on those with suspicious digital rectal examination (DRE) and or PSA >4ng/ml. A group of 849 Saudi men were with normal PSA levels and normal DRE were considered cancer free.. The remaining 151 patients with PSA >4ng/ml were suspicious for prostate cancer. Only 55 patients agreed to have TRUS and needle biopsy
RESULTS
PSA testing and DRE had the highest positive predictive value but this value dropped when TRUS was added.
CONCLUSION
PSA and DRE are the main tests for the detection of prostate cancer, while TRUS is valuable when sample are taken of a wide area of prostate tissue in men at high risk of cancer.
目的
预测沙特男性筛查试验在前列腺癌检测中的价值。
方法
该研究在胡拜尔法赫德国王大学医院进行。对45岁以上的沙特男性测量总血清前列腺特异性抗原（PSA）、游离PSA及游离PSA百分比。对直肠指检（DRE）可疑和/或PSA>4ng/ml者进行经直肠超声检查（TRUS）和穿刺活检。849名PSA水平正常且DRE正常的沙特男性被视为无癌。其余151名PSA>4ng/ml的患者疑似前列腺癌。只有55名患者同意进行TRUS和穿刺活检。
结果
PSA检测和DRE具有最高的阳性预测值，但加入TRUS后该值下降。
结论
PSA和DRE是前列腺癌检测的主要检查，而当对癌症高危男性的前列腺组织广泛取材时，TRUS很有价值。
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