Sunnerhagen K S, Bhargava V, Shabetai R
University of California, San Diego.
Am J Cardiol. 1990 Feb 1;65(5):364-70. doi: 10.1016/0002-9149(90)90303-i.
An evaluation and a comparison of left ventricular regional wall motion were performed in 32 patients with idiopathic dilated cardiomyopathy, none of whom had coronary artery diameter stenosis exceeding 20% in any major artery, and 17 control subjects, using frame by frame video intensity analysis of digitized ventriculograms. This technique evaluates the whole cardiac cycle in short overlapping intervals and yields information for systolic and diastolic events, without assumptions regarding the position and orientation of the ventricle. Diastolic regional wall motion abnormalities were found in 31 of 32 patients and systolic abnormalities were present in 16 patients. Asynchronous regions most commonly detected during diastole were anteroapical and apical; they were found in 19 of 32 patients. Regional contraction abnormality was observed in the apical and the anteroapical regions in 6 of 16 patients. Dilatation-induced changes in left ventricular shape exaggerate the phenomenon of higher wall stress at the apex of the normal ventricle. Basal wall motion is thus relatively preserved in dilated cardiomyopathy.
采用数字化心室造影的逐帧视频强度分析方法，对32例特发性扩张型心肌病患者和17例对照者进行了左心室局部壁运动的评估和比较。32例患者中无一例主要动脉的冠状动脉直径狭窄超过20%。该技术以短的重叠间期评估整个心动周期，并产生有关收缩期和舒张期事件的信息，而无需对心室的位置和方向进行假设。32例患者中有31例存在舒张期局部壁运动异常，16例存在收缩期异常。舒张期最常检测到的不同步区域是心尖前部和心尖部；32例患者中有19例出现这种情况。16例患者中有6例在心尖部和心尖前部区域观察到局部收缩异常。扩张导致的左心室形状改变夸大了正常心室心尖处壁应力较高的现象。因此，在扩张型心肌病中，基底壁运动相对保留。
