Ichihara Atsuhiro
Department of Endocrinology and Hypertension, Tokyo Women's Medical University.
Nihon Rinsho. 2012 Sep;70(9):1477-81.
While the circulating renin-angiotensin-aldosterone system(RAAS) plays an important role in the regulation of the sodium and extracellular fluid balance and blood pressure, the tissue RAAS has been reported to be involved in the pathophysiology of organ damage in patients with hypertension and diabetes. However, the regulation of the tissue RAAS, that is the production of angiotensin II and aldosterone within the tissue independently of the circulating RAAS, remains undetermined in detail. The purpose of this article is to review the recent advances in tissue RAAS research with a particular focus on the roles of (pro)renin receptor in the pathological conditions and its physiological function.
虽然循环中的肾素-血管紧张素-醛固酮系统（RAAS）在钠和细胞外液平衡及血压调节中起重要作用，但据报道组织RAAS参与了高血压和糖尿病患者器官损伤的病理生理过程。然而，组织RAAS的调节，即组织内独立于循环RAAS产生血管紧张素II和醛固酮的过程，仍未得到详细确定。本文的目的是综述组织RAAS研究的最新进展，特别关注（前）肾素受体在病理状态下的作用及其生理功能。
