Murohara Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine.
Nihon Rinsho. 2012 Sep;70(9):1577-81.
Heart failure (HF) is defined as an inability of the heart to supply sufficient blood flow to meet demand of the body. HF is characterized by an activation of various neurohumoral factors including the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS). Thus, medical treatments mainly consist of the blockade of the RAAS and/or SNS. In this chapter, the role of the RAAS inhibitors is discussed for the treatment of patients with HF.
心力衰竭(HF)的定义为心脏无法提供足够的血流以满足身体需求。HF的特征是各种神经体液因子的激活,包括肾素-血管紧张素-醛固酮系统(RAAS)和交感神经系统(SNS)。因此,药物治疗主要包括阻断RAAS和/或SNS。在本章中,将讨论RAAS抑制剂在HF患者治疗中的作用。