Lurie A A, Rogers W J, Gross L F
Department of Pathology, University of Alabama, Birmingham.
Am J Clin Pathol. 1990 Feb;93(2):246-51. doi: 10.1093/ajcp/93.2.246.
Twenty-two patients were infused with 240,000 units streptokinase during a 60-minute period into the ostium of the infarct-related coronary artery (IC), and 23 patients were infused with 1,500,000 units streptokinase intravenously (IV) over 45 minutes; all infusions occurred within 12 hours of the patients' onset of chest pain. Thereafter, heparin was infused for 10 days. Serial coagulation and fibrinolytic parameters were studied over 46 to 72 hours after the streptokinase infusion. A generalized fibrinolytic state was produced in both groups as evidenced by a fall in fibrinogen and plasminogen levels, prolongation of thrombin and reptilase clotting times, a rise in fibrinogen degradation products, and a shortening of the euglobulin lysis time. Recovery to preinfusion levels was similar in both groups of patients. Hemorrhagic complications requiring blood replacement occurred in 7/23 (30%) treated IC, and 4/23 (17%) in the IV group.
22例患者在60分钟内将240,000单位链激酶注入梗死相关冠状动脉（IC）开口处，23例患者在45分钟内静脉注射（IV）1,500,000单位链激酶；所有输注均在患者胸痛发作后12小时内进行。此后，肝素输注10天。在链激酶输注后46至72小时内研究系列凝血和纤溶参数。两组均产生了全身性纤溶状态，表现为纤维蛋白原和纤溶酶原水平下降、凝血酶和爬虫酶凝血时间延长、纤维蛋白原降解产物增加以及优球蛋白溶解时间缩短。两组患者恢复到输注前水平的情况相似。接受IC治疗的患者中有7/23（30%）发生需要输血的出血并发症，IV组中有4/23（17%）发生。
