Okada Motohiro
Department of Psychiatry, Graduate School of Medicine, Mie University.
Seishin Shinkeigaku Zasshi. 2012;114(8):974-82.
In the past two decades, we have identified various mutant genes associated with idiopathic epilepsies. Many of these mutant genes encode several ion channel subunits or functionally related proteins, leading to the classification of epilepsy as channelopathy. Currently, after the onset of epilepsy, we prescribe the anticonvulsant medication; however, anticonvulsants inhibit epileptic seizure and probably prevent progression of secondary epileptogenesis which is induced by epileptic seizure. Despite these efforts, we have no effective medication to prevent primary epileptogenesis. Thus, to develop novel strategies for the treatment of epilepsy, including preventing onset and complete recovery, we should develop true antiepileptic drug via generation of the genetic animal models of epilepsy according to the validation criteria.
在过去二十年中，我们已经鉴定出了各种与特发性癫痫相关的突变基因。其中许多突变基因编码几种离子通道亚基或功能相关蛋白，这使得癫痫被归类为离子通道病。目前，癫痫发作后，我们会开抗惊厥药物；然而，抗惊厥药可抑制癫痫发作，并可能预防由癫痫发作诱发的继发性癫痫发生的进展。尽管做出了这些努力，但我们仍没有有效的药物来预防原发性癫痫发生。因此，为了开发治疗癫痫的新策略，包括预防发作和完全康复，我们应该根据验证标准，通过建立癫痫基因动物模型来开发真正的抗癫痫药物。
