Sun Fei, Xu Bing-Hong
Department of Parasitology, Xinxiang Medical University, Xinxiang 453003, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012 Jun;24(3):358-61.
To deeply study the molecular mechanism of infection and reproduction of malaria parasites, this review began with co-relationship between toll like receptors (TLRs) and the parasites, further discussed how the parasites were recognized by TLRs and activated downstream inflammation reactions when the mechanical barrier of host was broken through. Some large molecules involved into the process had the potential to be novel drug targets.
为深入研究疟原虫感染和繁殖的分子机制，本综述首先探讨了Toll样受体（TLRs）与疟原虫之间的相互关系，进而讨论了当宿主的物理屏障被突破时，疟原虫如何被TLRs识别并激活下游炎症反应。参与这一过程的一些大分子有潜力成为新型药物靶点。
