Vasil'ev A V, Akhmerov K R, Salamov G G, Kazennova E V, Bobkova M R
Vopr Virusol. 2012 Jul-Aug;57(4):9-13.
The prevalence of the mutations associated with HIV fusion inhibitor enfuvirtide resistance in Russia and CIS countries was studied. Enfuvirtide resistance mutations were not observed among studied viruses in Russia and CIS countries so far. It was found that high rate (35%) of natural polymorphism mutations were associated with enfuvirtide hypersusceptibility. It was also found that high frequency of accessory mutations N126K and E137K were observed in the HR2 region (27.5%). The accessory mutations in HR2 can contribute to increased resistance and improve viral fitness. Our data were compared with those obtained in similar previous studies.
对俄罗斯和独联体国家中与HIV融合抑制剂恩夫韦肽耐药相关的突变流行情况进行了研究。目前在俄罗斯和独联体国家研究的病毒中未观察到恩夫韦肽耐药突变。研究发现，高比例（35%）的自然多态性突变与恩夫韦肽超敏感性相关。还发现，在HR2区域观察到辅助突变N126K和E137K的高频率（27.5%）。HR2中的辅助突变可能导致耐药性增加并改善病毒适应性。我们的数据与之前类似研究中获得的数据进行了比较。
