手性 N,N'-二氧化物-钪（III）配合物催化的硼氢化钾对烯酮的不对称 1,2-还原。
Asymmetric 1,2-reduction of enones with potassium borohydride catalyzed by chiral N,N'-dioxide-scandium(III) complexes.
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
出版信息
Org Lett. 2012 Oct 5;14(19):5134-7. doi: 10.1021/ol302430h. Epub 2012 Sep 26.
PMID:23013322
Abstract
The first catalytic enantioselective 1,2-reduction of enones with 0.45 mol equiv potassium borohydride solution catalyzed by a chiral N,N'-dioxide-Sc(III) complex catalyst was accomplished under mild reaction conditions. A number of optically active allylic alcohols were obtained in good to excellent enantioselectivities (up to 95% ee) with nearly quantitative yields.
摘要
首次使用手性 N,N'-二氧化物-Sc(III) 配合物催化剂，在温和的反应条件下，用 0.45 摩尔当量的硼氢化钾溶液催化烯酮的催化对映选择性 1,2-还原。许多具有良好至优异对映选择性（高达 95%ee）的手性烯丙醇几乎定量收率得到。
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