转录因子7样2基因rs7903146变异与2型糖尿病及肥胖相关参数的关系
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters.
作者信息
Kahveci Cigdem, Koldemir Meliha, Cagatay Penbe, Bayer Hikmet, Yildiz Sema, Bagriacik Nazif, Duman Belgin Susleyici
机构信息
Marmara University, Faculty of Science and Arts, Department of Biology, Istanbul, Turkey.
出版信息
Diabetes Metab Syndr. 2012 Jan-Mar;6(1):48-53. doi: 10.1016/j.dsx.2012.05.002. Epub 2012 Jun 5.
AIMS
The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined.
METHODS
TCF7L2 rs7903146 genotypes were determined with qPCR.
RESULTS
The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for controls. The weight, length and lean body mass were higher in C/T+T/T compared to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model assessment (HOMA) were nonsignificantly higher in rs7903146C/T+T/T in comparison to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. The absence of any difference between genotype frequencies among study groups indicates that no association persists with TCF7L2 gene rs7903146 polymorphism and T2DM.
CONCLUSIONS
The effects of rs7903146 variation over some obesity variables suggest that this variation may effect T2DM development via obesity.
目的
测定转录因子7样蛋白2（TCF7L2）基因rs7903146多态性在2型糖尿病（T2DM）患者及非T2DM对照人群中的等位基因频率。
方法
采用定量聚合酶链反应（qPCR）测定TCF7L2 rs7903146基因型。
结果
分别测定了T2DM患者中纯合野生型（C/C）、杂合型（C/T）和纯合多态型（T/T）的TCF7L2基因rs7903146基因型频率，分别为71.4%、14.3%、14.3%；对照人群中该基因型频率分别为72.5%、11.8%、15.7%。与C/C基因型携带者相比，C/T+T/T基因型携带者的体重、身高和去脂体重更高。与C/C基因型相比，rs7903146 C/T+T/T基因型携带者的血糖、胰岛素、胰岛素抵抗及稳态模型评估（HOMA）略高，但差异无统计学意义。未发现TCF7L2基因rs7903146基因型与药物之间存在相互作用。研究组间基因型频率无差异，表明TCF7L2基因rs7903146多态性与T2DM之间不存在关联。
结论
rs7903146变异对某些肥胖变量的影响表明，该变异可能通过肥胖影响T2DM的发生发展。
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