Mingroni-Netto R C, Rosenberg C, Vianna-Morgante A M, Pavanello R de C
Department of Biology, University of São Paulo, Brazil.
Am J Med Genet. 1990 Jan;35(1):22-7. doi: 10.1002/ajmg.1320350106.
Seventy-five male and 50 female students from 2 special schools for mildly, moderately retarded, or borderline individuals were screened clinically and cytogenetically in order to estimate the contribution of fragile X [fra(X)] syndrome to the cause of mental retardation in Brazil. We found 6 males (8%) from 4 families and 2 unrelated females (4%) with fra(X) chromosomes. One male and one female were isolated cases. The estimated frequency of Martin-Bell [fra(X)] syndrome among mentally impaired individuals in Brazil was similar to that previously reported in other countries.
对来自两所针对轻度、中度智力迟钝或临界个体的特殊学校的75名男学生和50名女学生进行了临床和细胞遗传学筛查，以评估脆性X [fra(X)] 综合征对巴西智力迟钝病因的影响。我们发现4个家庭中有6名男性（8%）和2名无关女性（4%）带有fra(X) 染色体。一名男性和一名女性为散发病例。巴西智力受损个体中Martin-Bell [fra(X)] 综合征的估计发病率与其他国家先前报告的相似。
