Cai H, Larsson S E, O Berg P A
J Biomed Opt. 1998 Jul;3(3):334-9. doi: 10.1117/1.429892.
Single fiber, laser-Doppler flowmetry can be used for blood flow measurement in deeply located tissue structures by the insertion of optical fibers into the tissue. The geometry of the monitored volume has been estimated at two different wavelengths and when using two types of fiber tips, one of which has been modified with a lens formed at the fiber end surface. Physical models as well as intramuscular measurements have been used in the experiments. The scattering image was studied in latex solutions of three different scatterer concentrations. The wavelengths 632.8 and 750 nm were used. At higher concentrations of scatterers, the near infrared (NIR) wavelength gave a larger scattering area. At the lower concentration, the difference between the areas was smaller or nonexistent. The NIR wavelength also showed an increased monitoring depth than that of the He-Ne laser in an experimental model study. The properties of the tip optics were evaluated in a flow-through model where the distance between the fiber tips and the flow channel was varied. The flat tip fiber has a sensitivity maximum close to its end surface, whereas the modified fiber ("pear" tip) showed a sensitivity maximum 1.5 mm from the end surface. This property may decrease the influence caused by the insertion trauma in intramuscular measurements. © 1998 Society of Photo-Optical Instrumentation Engineers.
单纤维激光多普勒血流仪可通过将光纤插入组织来测量深部组织结构中的血流。在两种不同波长下以及使用两种类型的光纤探头(其中一种在光纤端面形成有透镜进行了改性)时,对监测体积的几何形状进行了估计。实验中使用了物理模型以及肌肉内测量。在三种不同散射体浓度的乳胶溶液中研究了散射图像。使用的波长为632.8和750纳米。在较高浓度的散射体下,近红外(NIR)波长给出的散射面积更大。在较低浓度下,面积之间的差异较小或不存在。在实验模型研究中,近红外波长的监测深度也比氦氖激光的监测深度增加。在一个流通模型中评估了探头光学器件的特性,其中光纤探头与流动通道之间的距离是变化的。平头光纤在靠近其端面处灵敏度最高,而改性光纤(“梨形”探头)在距端面1.5毫米处灵敏度最高。这一特性可能会降低肌肉内测量中插入创伤所造成的影响。©1998年美国光电仪器工程师协会。