晚期人类免疫缺陷病毒感染女性孕期的严重感染

Serious infections during pregnancy among women with advanced human immunodeficiency virus infection.

作者信息

Minkoff H L, Willoughby A, Mendez H, Moroso G, Holman S, Goedert J J, Landesman S H

机构信息

Department of Obstetrics and Gynecology, SUNY-Health Science Center, Brooklyn 11203-2098.

出版信息

Am J Obstet Gynecol. 1990 Jan;162(1):30-4. doi: 10.1016/0002-9378(90)90814-n.

DOI:10.1016/0002-9378(90)90814-n

PMID:2301513

Abstract

Fifty-six human immunodeficiency virus seropositive-women and 76 human immunodeficiency virus seronegative-women had known CD4 cell values and were followed up throughout pregnancy. The women with seronegative results and the 40 with seropositive results and CD4 (helper cell) counts consistently greater than 300 cells/mm3 had no serious infections during pregnancy. Among the 16 with seropositive results and counts that fell below 300 cells/mm3, three developed opportunistic infections, one had pneumonia, and one had a post-cesarean-section abscess. Human immunodeficiency virus seropositive-women with low CD4 counts are at markedly increased risk of serious infections during pregnancy. The consequences of this for fetal health, pregnancy management, maternal well-being, and human immunodeficiency virus testing policies are discussed.

摘要

56名人类免疫缺陷病毒血清反应阳性的女性和76名人类免疫缺陷病毒血清反应阴性的女性已知其CD4细胞值，并在整个孕期接受随访。血清反应阴性的女性以及40名血清反应阳性且CD4（辅助细胞）计数持续大于300个细胞/立方毫米的女性在孕期未发生严重感染。在16名血清反应阳性且计数低于300个细胞/立方毫米的女性中，3人发生机会性感染，1人患肺炎，1人发生剖宫产术后脓肿。CD4计数低的人类免疫缺陷病毒血清反应阳性女性在孕期发生严重感染的风险显著增加。本文讨论了这对胎儿健康、孕期管理、母亲健康以及人类免疫缺陷病毒检测政策的影响。