Antonov E N, Bagratashvili V N, Popov V K, Sobol E N, Howdle S M, Joiner C, Parker K G, Parker T L, Doktorov A A, Likhanov V B, Volozhin A I, Alimpiev S S, Nikiforov S M
J Biomed Opt. 1998 Oct;3(4):423-8. doi: 10.1117/1.429852.
We have investigated the biocompatibility of calcium phosphate coatings deposited by pulsed laser ablation from hydroxyapatite (HA) targets onto polyethylene and Teflon substrates. It was found that the cell density, attachment, and morphology of primary rat calvaria osteoblasts were influenced by both the original polymer and by the nature of the apatite coatings. HA coatings on Teflon were found to have higher biocompatibility in terms of cell adhesion and spreading. In vivo studies of bone response to coatings deposited by KrF excimer and CO2 lasers on commercial Ti6A14V alloy implants show that both deposition techniques suppress fibrous tissue formation and promote osteogenesis. © 1998 Society of Photo-Optical Instrumentation Engineers.
我们研究了通过脉冲激光烧蚀从羟基磷灰石（HA）靶材沉积到聚乙烯和聚四氟乙烯基底上的磷酸钙涂层的生物相容性。结果发现，原聚合物以及磷灰石涂层的性质均会影响原代大鼠颅骨成骨细胞的细胞密度、附着情况和形态。在细胞黏附和铺展方面，聚四氟乙烯上的HA涂层具有更高的生物相容性。对KrF准分子激光和CO2激光沉积在商用Ti6A14V合金植入物上的涂层的骨反应进行的体内研究表明，这两种沉积技术均能抑制纤维组织形成并促进骨生成。© 1998 光电仪器工程师协会。
