Baudemont Céline, Merlet Isabelle, du Boisgueheneuc Foucaud, Liuu Évelyne, Tartarin Florence, Ragot Stéphanie, Paccalin Marc
Centre mémoire de ressources et de recherche, CHU La Milétrie, Poitiers, France.
Geriatr Psychol Neuropsychiatr Vieil. 2012 Sep;10(3):277-83. doi: 10.1684/pnv.2012.0366.
Behavioral and psychological symptoms of dementia (BPSD) are frequent and belong to the natural evolution of the disease. Specialized cognitive-behavioral units (Unités cognitivo-comportementales) were created, in France (plan Alzheimer 2008-2012), to cope with this problem. Despite a stay in such a unit, some patients have to be rehospitalized. The main aim of the current study was to highlight the predictive factors of readmissions.
Descriptive, retrospective study of demented patients ≥75 years, hospitalized between January 2010 and April 2011. We compared patients that had to be rehospitalized within 3 months (group 1), with the patients that did not need to be rehospitalized or after 3 months of time (group 2). Patients characteristics included: basic daily living activities (French GIR score), MMSE score, neuropsychiatric inventory score, type of BPSD, length of stay and antipsychotropic drugs.
Two hundred thirty-five patients were included including, 147 women (62.5%), with mean age of 82.74±7.13 years. SPCD was the main reason for hospitalization. Thirty patients (12.77%) belonged to group 1. The mean number of psychotropic treatments increased during the stay (p=0.02), particularly in group 2 (p=0.01). The NPI score decreased during the hospitalization in both groups. Linear regression analysis showed that behavioral type of symptoms (OR: 3.18; 95% CI 1.32-7.65) and association of antidepressant and antipsychotic drugs (OR: 4.77; 95% CI 1.35-16.83) were significantly predictive of an early readmission. The risk of readmission also significantly decreased as the length of stay increased.
This work confirms the specificity and the need for such units. The results will help improving the outcome of demented patients with BPSD and treated with different antipsychotropic drugs.
痴呆的行为和心理症状(BPSD)很常见,属于该疾病的自然演变过程。法国(2008 - 2012年阿尔茨海默病计划)设立了专门的认知行为单元(Unités cognitivo - comportementales)来应对这一问题。尽管在这样的单元中接受治疗,但仍有一些患者需要再次住院。本研究的主要目的是找出再次入院的预测因素。
对2010年1月至2011年4月期间住院的75岁及以上痴呆患者进行描述性回顾性研究。我们将在3个月内必须再次住院的患者(第1组)与不需要再次住院或在3个月后才再次住院的患者(第2组)进行了比较。患者特征包括:基本日常生活活动能力(法国GIR评分)、MMSE评分、神经精神科问卷评分、BPSD类型、住院时间和抗精神病药物使用情况。
共纳入235例患者,其中147例女性(62.5%),平均年龄82.74±7.13岁。严重精神行为障碍是住院的主要原因。30例患者(12.77%)属于第1组。住院期间精神药物治疗的平均次数增加(p = 0.02),尤其是在第2组(p = 0.01)。两组患者住院期间NPI评分均下降。线性回归分析显示,行为症状类型(OR:3.18;95%CI 1.32 - 7.65)以及抗抑郁药和抗精神病药联合使用(OR:4.77;95%CI 1.35 - 16.83)是早期再次入院的显著预测因素。再次入院风险也随着住院时间的延长而显著降低。
这项研究证实了此类单元的特殊性和必要性。研究结果将有助于改善患有BPSD并接受不同抗精神病药物治疗的痴呆患者的治疗效果。