Nicolaidis S, Galaverna O, Metzler C H
Laboratoire de Neurobiologie des Régulations, Centre National de la Recherche Scientifique, Collège de France, Paris.
Am J Physiol. 1990 Jan;258(1 Pt 2):R281-3. doi: 10.1152/ajpregu.1990.258.1.R281.
The propensity to prefer and to consume salty foods varies considerably from person to person, and excessive salt intake has been linked to a number of pathological conditions. Extracellular dehydration occurs in humans after vomiting or diarrhea and is commonly observed during pregnancy. Because the hormonal responses to extracellular dehydration are known to increase salt appetite, we tested the hypothesis that extracellular dehydration during pregnancy increases the propensity of offspring to consume salt. Pregnant rats were treated with polyethylene glycol, which is known to produce extracellular dehydration and to exaggerate sodium appetite. The offspring of these treated pregnant rats showed an increase in salt appetite as compared with the offspring of control untreated dams. These results demonstrate that extracellular dehydration during pregnancy can enhance the natriophilic propensity in offspring and suggest that gravidic vomiting may contribute to the epidemiological factors of hypertension and other pathologies.
偏爱和食用咸味食物的倾向在人与人之间差异很大，过量摄入盐已与多种病理状况相关联。人体在呕吐或腹泻后会发生细胞外脱水，孕期也常见这种情况。由于已知对细胞外脱水的激素反应会增加对盐的食欲，我们检验了这样一个假设：孕期的细胞外脱水会增加后代食用盐的倾向。给怀孕大鼠注射聚乙二醇，已知聚乙二醇会导致细胞外脱水并增强对钠的食欲。与未接受处理的对照母鼠的后代相比，这些接受处理的怀孕大鼠的后代对盐的食欲有所增加。这些结果表明，孕期的细胞外脱水可增强后代对钠的偏好倾向，并提示妊娠呕吐可能是导致高血压和其他病症的流行病学因素之一。
