Wang Fengjiao, Zhuang Jinpeng, Zhou Lei, Yan Jinglong
Department of Orthopedic Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012 Aug;29(4):798-802.
Magnesium based implants have the characteristics of bio-degradability, osteoconductive, and, regulatory strength. After the tissue has healed sufficiently, the burden of a second surgical procedure can be avoided. However, the degradation speed is so fast as to limit its clinical application. Hence, it is crucial for the biomedical magnesium alloys to be able to change their biodegradation behavior and speed. This paper reviews the degradability, biological activity and biocompatibility of magnesium and its alloys as orthopedic biomaterial in vitro and vivo to explore the possible way to modify the characteristics of its degradability, for the purpose of controllable degradation speed.
镁基植入物具有生物可降解性、骨传导性和强度调节特性。在组织充分愈合后，可以避免二次手术的负担。然而，其降解速度过快，限制了其临床应用。因此，对于生物医学镁合金来说，能够改变其生物降解行为和速度至关重要。本文综述了镁及其合金作为骨科生物材料在体外和体内的可降解性、生物活性和生物相容性，以探索改变其降解特性的可能方法，实现降解速度可控。
