College of Chemical Engineering, AnHui University of Science & Technology, Huainan 232001, P.R. China.
Mini Rev Med Chem. 2013 Jun 1;13(8):1160-5. doi: 10.2174/1389557511313080004.
The research and development of calixarenes, cyclodextrins and fullerenes, which constitute the major classes of supramolecular organic host compounds, have been quite rapidly developing, increasingly active and newly rising highlight interdisciplinary fields. Numerous efforts have been directed toward such molecules as new platforms for anti- HIV drug design. This work briefly reviewed the recent development of calixarenes, cyclodextrins and fullerenes as new chemical entities of distinct anti-HIV activities. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic biological molecules as anti-HIV drugs.
杯芳烃、环糊精和富勒烯的研究与开发构成了超分子有机主体化合物的主要类别，发展非常迅速，越来越活跃，新的亮点不断涌现，成为跨学科领域。人们已经投入了大量的努力，将这些分子作为设计抗 HIV 药物的新平台。本文简要综述了杯芳烃、环糊精和富勒烯作为具有不同抗 HIV 活性的新化学实体的最新研究进展。希望这篇综述能为寻找更有效、毒性更低的生物分子作为抗 HIV 药物的合理设计提供新的思路。
