Correale Michele, Abruzzese Silvia, Greco Carmen Adriana, Concilio Morena, Di Biase Matteo, Brunetti Natale Daniele
Department of Cardiology, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy.
Curr Vasc Pharmacol. 2012 Sep 20.
Clinical trials demonstrated that statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality when used for either primary or secondary prevention of cardiovascular events. Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent heart failure (HF) in patients with coronary artery disease. This review summarizes the experimental and clinical evidence regarding the role of statins in the management of HF.
临床试验表明，他汀类药物疗法用于心血管事件的一级或二级预防时，可显著降低心血管发病率和死亡率。多项研究表明，他汀类药物在预防急性冠状动脉综合征方面具有重要作用，还能够预防冠状动脉疾病患者发生心力衰竭（HF）。本综述总结了关于他汀类药物在心力衰竭管理中作用的实验和临床证据。
