Bai S L, Campbell S E, Moore J A, Morales M C, Gerdes A M
Department of Anatomy, College of Medicine, University of South Florida, Tampa 33612.
Anat Rec. 1990 Feb;226(2):207-12. doi: 10.1002/ar.1092260210.
The effects of altered neonatal nutrition on cardiac myocyte size and number was examined in 21-day-old and 3-month-old rats. Nutritional differences in growth rate were produced in newborns by adjusting litter size to four (fast-growing), eight (normally growing), or 16 (slow-growing) pups per litter. Isolated myocytes were prepared from animals in each group to evaluate changes in cell size and number. Heart weight (mg +/- S.D.), at 21 days of age, was 398 +/- 51 for "fast-growing" rats, 329 +/- 43 for "normally growing" rats, and 228 +/- 24 for "slow-growing" rats. Body weights showed a comparable decline with reduced nutrition. In adults, treatment-related differences in body and heart weight were present in males but not females. "Slow-growing" rats had 21% fewer myocytes than "fast-growing" rats at 21 days of age, a change that persisted in adults. Values for myocyte number from "normally growing" rats were intermediate between those of "fast and slow-growing" rats at both 21 days and 3 months of age. In each heart region of weanling rats, myocyte length and volume were smallest in 16 per litter rats. Cellular dimensions increased progressively with better nutrition.(ABSTRACT TRUNCATED AT 250 WORDS)
在21日龄和3月龄大鼠中研究了新生期营养改变对心肌细胞大小和数量的影响。通过将每窝幼崽数量调整为4只（生长快）、8只（正常生长）或16只（生长慢）来制造新生大鼠生长速率的营养差异。从每组动物中分离出心肌细胞，以评估细胞大小和数量的变化。21日龄时，“生长快”大鼠的心脏重量（毫克±标准差）为398±51，“正常生长”大鼠为329±43，“生长慢”大鼠为228±24。体重也随着营养减少而出现类似下降。在成年大鼠中，雄性存在与治疗相关的体重和心脏重量差异，雌性则没有。21日龄时，“生长慢”大鼠的心肌细胞比“生长快”大鼠少21%，这一变化在成年大鼠中持续存在。在21日龄和3月龄时，“正常生长”大鼠的心肌细胞数量值介于“生长快”和“生长慢”大鼠之间。在断奶大鼠的每个心脏区域，每窝16只大鼠的心肌细胞长度和体积最小。随着营养状况改善，细胞尺寸逐渐增加。（摘要截选至250字）
