Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
J Cyst Fibros. 2013 May;12(3):271-6. doi: 10.1016/j.jcf.2012.08.012. Epub 2012 Sep 25.
Recent studies have identified hypertriglyceridemic cystic fibrosis patients (CF-TG). However, whether hypertriglyceridemia is associated with an altered metabolic profile remains unknown.
To characterize CF-TG and determine whether triglycerides (TG) levels are associated with metabolic alterations.
210 adult CF subjects from the Montreal Cystic Fibrosis Cohort without known diabetes were included in the analysis. All subjects underwent an OGTT to assess glucose tolerance, insulin secretion (insulin AUC) and insulin sensitivity (Stumvoll index). Fasting lipid profiles, pulmonary function (%FEV1) and BMI were determined. Hypertriglyceridemia (TG>1.7mmol/L) was observed in 20 CF patients. These subjects were matched for age, sex and glucose tolerance category with 20 CF patients (CF-normal-TG) and 20 healthy controls that had TG levels below 1.7mmol/L. Pearson correlations were performed in the complete study sample (n=210) to examine the associations between TG levels and other parameters.
The prevalence of hypertriglyceridemia was 9.5%. Compared to CF-normal-TG, CF-TG subjects displayed significantly higher %FEV1, insulin AUC (AUC0-120, AUC0-30, AUC30-120), cholesterol levels and a higher ratio of total cholesterol to HDL-cholesterol. Pearson analysis demonstrated that TG levels were associated with BMI, %FEV1, fasting insulin, insulin AUC0-120 and AUC30-120, Stumvoll index, cholesterol levels and the ratio of total cholesterol to HDL-cholesterol. All these correlations remained significant after correction for BMI except %FEV1.
TG levels are associated with a mild alteration of the metabolic profile. Whether these changes will increase the long-term risk of CF patients in developing cardiometabolic complications remains to be investigated.
最近的研究已经确定了高甘油三酯血症的囊性纤维化患者（CF-TG）。然而，高甘油三酯血症是否与代谢谱的改变有关仍不清楚。
描述 CF-TG，并确定甘油三酯（TG）水平是否与代谢改变有关。
本研究纳入了来自蒙特利尔囊性纤维化队列的 210 名无已知糖尿病的成年 CF 患者。所有患者均接受 OGTT 以评估葡萄糖耐量、胰岛素分泌（胰岛素 AUC）和胰岛素敏感性（Stumvoll 指数）。测定空腹血脂谱、肺功能（%FEV1）和 BMI。观察到 20 名 CF 患者存在高甘油三酯血症（TG>1.7mmol/L）。这些患者按年龄、性别和葡萄糖耐量类别与 20 名 CF 患者（CF-TG 正常）和 20 名 TG 水平低于 1.7mmol/L 的健康对照者相匹配。在整个研究样本（n=210）中进行 Pearson 相关性分析，以检查 TG 水平与其他参数之间的相关性。
高甘油三酯血症的患病率为 9.5%。与 CF-TG 正常相比，CF-TG 患者的 %FEV1、胰岛素 AUC（AUC0-120、AUC0-30、AUC30-120）、胆固醇水平和总胆固醇与高密度脂蛋白胆固醇的比值明显更高。Pearson 分析表明，TG 水平与 BMI、%FEV1、空腹胰岛素、胰岛素 AUC0-120 和 AUC30-120、Stumvoll 指数、胆固醇水平和总胆固醇与高密度脂蛋白胆固醇的比值相关。除 %FEV1 外，所有这些相关性在校正 BMI 后仍然显著。
TG 水平与代谢谱的轻微改变有关。这些变化是否会增加 CF 患者发生心血管代谢并发症的长期风险仍有待研究。
