鼠伤寒沙门氏菌温度敏感型泛酸激酶突变体的分离及coaA基因的定位
Isolation of temperature-sensitive pantothenate kinase mutants of Salmonella typhimurium and mapping of the coaA gene.
作者信息
Dunn S D, Snell E E
出版信息
J Bacteriol. 1979 Dec;140(3):805-8. doi: 10.1128/jb.140.3.805-808.1979.
Abstract
Temperature-sensitive pantothenate kinase mutants of Salmonella typhimurium LT2 were selected by using the excretion of pantothenate at the nonpermissive temperature as a screening method. Thermolability of the pathothenate kinase activity in extracts of the mutants was demonstrated. The mutations were mapped at min 89 of the Salmonella chromosome, near rpoB, by transduction. As pantothenate kinase catalyzes the first step in the biosynthesis of coenzyme A from pantothenate, the new genetic locus has been designated coaA.
摘要
利用鼠伤寒沙门氏菌LT2在非允许温度下泛酸盐的排泄作为筛选方法，筛选出了温度敏感型泛酸盐激酶突变体。已证明这些突变体提取物中泛酸盐激酶活性具有热不稳定性。通过转导将这些突变定位在沙门氏菌染色体89分钟处，靠近rpoB。由于泛酸盐激酶催化从泛酸盐生物合成辅酶A的第一步，这个新的基因位点被命名为coaA。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
Phosphorylation of pantothenic acid and pantethine by an enzyme from Proteus morganii.摩根变形杆菌中一种酶对泛酸和泛硫乙胺的磷酸化作用。
J Biol Chem. 1955 Apr;213(2):869-76.
3
UPTAKE OF AMINO ACIDS BY SALMONELLA TYPHIMURIUM.鼠伤寒沙门氏菌对氨基酸的摄取
Arch Biochem Biophys. 1964 Jan;104:1-18. doi: 10.1016/s0003-9861(64)80028-x.
4
The metabolism of pantothenic acid.泛酸的代谢
J Biol Chem. 1959 Feb;234(2):370-8.
5
Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
J Biol Chem. 1956 Jan;218(1):97-106.
6
The phosphorylation of pantothenic acid by Lactobacillus arabinosus 17-5.阿拉伯糖乳杆菌17-5对泛酸的磷酸化作用
Biochem J. 1955 Nov;61(3):368-74. doi: 10.1042/bj0610368.
7
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