UO Clinica Pediatrica, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Parma, Via Gramsci 14 IT-43100 Parma, Italy.
Respiration. 2012;84(4):291-8. doi: 10.1159/000341969. Epub 2012 Sep 27.
In asthmatics, the concentration of hydrogen peroxide (H(2)O(2)) in exhaled breath condensate (EBC) has been found to be increased and to be related to airway inflammation.
The aim of this study was to determine whether in children with acute exacerbation, exhaled H(2)O(2) levels could be influenced by treatment and linked to airway obstruction.
Twenty-two asthmatic children (mean age 9.4 years, range 6-14) with asthma exacerbation and 12 healthy children (mean age 11.7 years, range 7-15) were enrolled. Concentrations of exhaled H(2)O(2) before and after standard treatment for asthma attack were compared with those of controls and with clinical observation. Asthmatic children and controls underwent spirometry and skin prick tests to common aeroallergens.
Exhaled H(2)O(2) concentrations were significantly higher in children with asthma both before (median 0.273 µM; p < 0.001) and after pharmacologic treatment (median 0.303 µM; p = 0.001) compared to control values (median 0.045 µM). After treatment, exhaled H(2)O(2) concentrations remained significantly higher in children with and without auscultatory wheezing than in controls (p = 0.034 and p < 0.001, respectively). EBC H(2)O(2) levels in asthmatics before treatment did not differ from those after treatment. No correlation was found between H(2)O(2) and forced expiratory volume in 1 s values. All asthmatics but one were atopics.
In children with acute asthma exacerbation, exhaled H(2)O(2) concentrations in EBC are significantly elevated. In the short-term follow-up, H(2)O(2) levels remain at high levels and are not correlated with lung function or improvement in symptoms.
在哮喘患者中，呼气冷凝液（EBC）中的过氧化氢（H₂O₂）浓度升高，并与气道炎症有关。
本研究旨在确定在急性加重期的儿童中，呼出的 H₂O₂水平是否可以通过治疗来影响，并与气道阻塞相关联。
招募了 22 名哮喘发作的哮喘儿童（平均年龄 9.4 岁，范围 6-14 岁）和 12 名健康儿童（平均年龄 11.7 岁，范围 7-15 岁）。比较了哮喘发作患儿在接受标准哮喘治疗前后的呼出 H₂O₂浓度与对照组的浓度以及与临床观察的关系。哮喘儿童和对照组进行了肺功能检查和常见变应原的皮肤点刺试验。
哮喘儿童在接受药物治疗前后的呼出 H₂O₂浓度均显著高于对照组（中位数 0.273 µM；p < 0.001 和中位数 0.303 µM；p = 0.001）。在治疗后，有和无听诊哮鸣音的儿童的呼出 H₂O₂浓度仍显著高于对照组（p = 0.034 和 p < 0.001）。在治疗前，哮喘患儿的 EBC H₂O₂水平与治疗后无差异。未发现 H₂O₂与 1 秒用力呼气量（FEV₁）值之间存在相关性。所有哮喘患儿均为特应性个体。
在急性哮喘加重的儿童中，EBC 中的呼出 H₂O₂浓度显著升高。在短期随访中，H₂O₂水平仍处于较高水平，与肺功能或症状改善无相关性。
