Regenerative Medicine Institute (REMEDI), National Centre for Biomedical Engineering Science (NCBES) and School of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
Kidney Int. 2012 Oct;82(8):835-7. doi: 10.1038/ki.2012.164.
Mononuclear phagocytes (macrophages, dendritic cells, and monocytes) play a complex role in kidney disease. Techniques for selectively depleting them in rodents have made important contributions but have also generated some contradictory results. Ferenbach et al. report that two widely used mononuclear phagocyte depletion techniques differentially affect early severity of renal ischemia/reperfusion injury and provide evidence that this may be due to a residual, protective subset that persists in the kidney after one of the two techniques.
单核吞噬细胞（巨噬细胞、树突状细胞和单核细胞）在肾脏疾病中发挥着复杂的作用。在啮齿动物中选择性清除它们的技术做出了重要贡献，但也产生了一些相互矛盾的结果。Ferenbach 等人报告说，两种广泛使用的单核吞噬细胞清除技术对肾缺血/再灌注损伤的早期严重程度有不同的影响，并提供了证据表明，这可能是由于其中一种技术后，肾脏中仍存在一个残留的、保护性的亚群。
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