水痘相关性血小板减少症中的血小板抗原
Platelet antigens in varicella associated thrombocytopenia.
作者信息
Winiarski J
机构信息
Department of Paediatrics, Karolinska Institute Huddinge Hospital, Sweden.
出版信息
Arch Dis Child. 1990 Jan;65(1):137-9. doi: 10.1136/adc.65.1.137.
Abstract
Serum IgG or, predominantly, IgM antibody binding to electrophoretically separated normal platelet membrane protein antigens were detected by immunoblotting in five children with thrombocytopenia associated with varicella. Glycoproteins GPIb, GPIIb, GPIIIa, and other 25-260 kilodalton (kDa) proteins were identified as target antigens, suggesting a transient autoimmune mechanism causing the thrombocytopenia.
摘要
通过免疫印迹法在5例水痘相关性血小板减少症患儿中检测到血清IgG，主要是IgM抗体与经电泳分离的正常血小板膜蛋白抗原结合。糖蛋白GPIb、GPIIb、GPIIIa以及其他25 - 260千道尔顿（kDa）的蛋白被确定为靶抗原，提示存在一种导致血小板减少的短暂自身免疫机制。
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