Soares Eduardo Costa Studart, Quidute Ana Rosa Pinto, Costa Fábio Wildson Gurgel, Gurgel Maria Helane Costa, Alves Ana Paula Negreiros Nunes, Fonteles Cristiane Sá Roriz
Division of Oral Surgery, Department of Clinical Dentistry, Federal University of Ceará, Brazil.
J Clin Pediatr Dent. 2012 Summer;36(4):377-81. doi: 10.17796/jcpd.36.4.aq167251703n767u.
Langerhans'cell histiocytosis (LCH) comprises a rare group of reticuloendothelial system disorders that can produce focal or systemic manifestations. Diabetes insipidus is considered to be an important indicator of serious underlying diseases in children, including LCH. We report the case of a young patient with monostotic LCH confined to the mandibular ramus, who was diagnosed with the disease after presenting symptoms of central diabetes insipidus and was satisfactorily treated with multi-agent chemotherapy. Additionally, we discuss the clinical, radiographic, histological and immunohistochemical findings, as well as the multidisciplinary approach of this important disease, which should receive attention by dental practitioners, especially when it occurs in children.
朗格汉斯细胞组织细胞增多症（LCH）是一组罕见的网状内皮系统疾病，可产生局部或全身表现。尿崩症被认为是包括LCH在内的儿童严重潜在疾病的重要指标。我们报告了一例局限于下颌支的单骨性LCH年轻患者，该患者在出现中枢性尿崩症症状后被诊断出患有该病，并通过多药化疗得到了满意的治疗。此外，我们还讨论了该重要疾病的临床、影像学、组织学和免疫组化结果，以及多学科诊疗方法，牙科医生应关注该疾病，尤其是当它发生在儿童身上时。
