Su Yun-Chao, Wu Li-Ling, Xiang Ruo-Lan
Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.
Sheng Li Ke Xue Jin Zhan. 2012 Jun;43(3):171-6.
Sjögren's syndrome is a chronic autoimmune disease, the pathogenesis of which still remains to be explored. Non-obese diabetic (NOD) mouse, presenting impairment of secretory function as well as the development of sialoadenitis, which is in common with human Sjögren's syndrome, is considered as one of the appropriate animal models for the study of Sjögren's syndrome. With regard to genetic factors, apoptosis, autoantibodies and cytokines, this paper reviewed the progress in understanding the pathogenesis of Sjögren's syndrome in NOD mice.
干燥综合征是一种慢性自身免疫性疾病，其发病机制仍有待探索。非肥胖糖尿病（NOD）小鼠出现分泌功能受损以及涎腺炎，这与人类干燥综合征相同，被认为是研究干燥综合征的合适动物模型之一。本文从遗传因素、细胞凋亡、自身抗体和细胞因子方面综述了对NOD小鼠干燥综合征发病机制的认识进展。
