Soldati S, Radaelli E, Mazzuti A, Scanziani E
IDEXX-Diavet, Division of IDEXX Laboratories, Diavet-Labor AG, Bäch, Switzerland.
J Small Anim Pract. 2012 Dec;53(12):709-13. doi: 10.1111/j.1748-5827.2012.01289.x. Epub 2012 Oct 1.
An 18-month-old male basset hound was presented with vomiting, diarrhoea and depression. Abdominal ultrasonography revealed a mass in the left kidney. An ultrasound-guided core-biopsy indicated aggregates of spindle cells, but did not allow a definitive diagnosis. Nephrectomy was performed after a period of six months, when ultrasound examination revealed a slight increase in mass dimensions. Histologically the mass was composed of neoplastic spindle cells forming interlacing fascicles, bundles and whorls, within a loose myxoid to dense collagenous stroma. Immunohistochemically neoplastic cells were positive for vimentin and smooth muscle actin. Based on these findings the tumour was diagnosed as a congenital mesoblastic nephroma, classical variant. After a two-and-a-half-year follow-up the dog was clinically healthy, indicating a benign behaviour. To the authors' knowledge, this report describes the first case of canine congenital mesoblastic nephroma successfully treated surgically, with a reasonable postsurgical follow-up.
一只18个月大的雄性巴吉度猎犬出现呕吐、腹泻和精神沉郁症状。腹部超声检查发现左肾有一个肿块。超声引导下的穿刺活检显示有梭形细胞聚集，但无法做出明确诊断。六个月后，当超声检查显示肿块尺寸略有增加时，进行了肾切除术。组织学检查显示，肿块由肿瘤性梭形细胞组成，形成交织的束状、条索状和漩涡状结构，位于疏松的黏液样至致密的胶原性基质中。免疫组织化学检查显示肿瘤细胞波形蛋白和平滑肌肌动蛋白呈阳性。基于这些发现，该肿瘤被诊断为先天性中胚叶肾瘤，经典型。经过两年半的随访，这只狗临床健康，表明该肿瘤行为良性。据作者所知，本报告描述了首例成功接受手术治疗并进行合理术后随访的犬先天性中胚叶肾瘤病例。
