Department of Orthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Orthod Craniofac Res. 2012 Nov;15(4):207-36. doi: 10.1111/j.1601-6343.2012.01552.x. Epub 2012 Aug 16.
The objective of the study was to systematically summarize current evidence on the effectiveness of pre-surgical infant orthopedics (PSIO) in cleft lip and palate (CLP) patients. Electronic and manual searches were conducted, and using specific inclusion and exclusion criteria, data extraction and analysis was performed by two independent investigators. When possible, overall pooled estimates with 95% confidence intervals were obtained using the random-effects model. Twenty-four of 885 original studies met the inclusion criteria and were included in the qualitative synthesis, whereas 10 of them were included in the quantitative synthesis (meta-analysis). Except for the variable M-T-C(5) assessing maxillary arch form, which presented an increase at 48 months of follow-up, all other variables concerning craniofacial and dentoalveolar changes demonstrated no significant differences, indicating that PSIO treatment has no effect on CLP patients. The limited evidence derived from this study does not seem to support the short- or long-term effectiveness of PSIO in CLP patients.
本研究的目的是系统总结目前关于唇腭裂（CLP）患者术前正畸（PSIO）有效性的证据。通过电子和手动搜索，并使用特定的纳入和排除标准，由两名独立的研究者进行数据提取和分析。在可能的情况下，使用随机效应模型获得具有 95%置信区间的总体汇总估计值。在 885 项原始研究中，有 24 项符合纳入标准并被纳入定性综合分析，其中 10 项被纳入定量综合分析（荟萃分析）。除了评估上颌弓形态的 M-T-C(5)变量在随访 48 个月时呈现增加外，所有其他涉及颅面和牙牙槽变化的变量均未显示出显著差异，表明 PSIO 治疗对 CLP 患者没有影响。本研究得出的有限证据似乎不支持 PSIO 在 CLP 患者中的短期或长期有效性。
