Yokoyama Keitaro
Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Clin Calcium. 2012 Oct;22(10):1531-6.
α-Klotho was first identified as an aging gene and was later shown to be a regulator of mineral metabolism. Then, α-Klotho was reported to function as an obligate coreceptor for fibroblast growth factor 23 (FGF23). Phosphrus regulation of FGF23/Klotho axis is slow. On the other hand, α-Klotho is a key player that integrates "a multi-step regulatory system of calcium homeostasis" that rapidly adjusts the extracellular calcium concentration. In addition to its membrane-bound function as a co-receptor for fibroblast growth factor 23, soluble Klotho exerts effects as a circulating substance in plasma and urine. The Klotho protein not only serves as a coreceptor for FGF23, but also functions as a humoral factor.
α-klotho最初被鉴定为一种衰老基因，后来被证明是矿物质代谢的调节因子。随后，有报道称α-klotho作为成纤维细胞生长因子23（FGF23）的必需共受体发挥作用。FGF23/klotho轴对磷的调节作用缓慢。另一方面，α-klotho是整合“快速调节细胞外钙浓度的多步骤钙稳态调节系统”的关键因子。除了作为成纤维细胞生长因子23的共受体发挥膜结合功能外，可溶性klotho还作为血浆和尿液中的循环物质发挥作用。Klotho蛋白不仅作为FGF23的共受体，还作为一种体液因子发挥作用。
