Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
Neuropathology. 2013 Jun;33(3):320-3. doi: 10.1111/j.1440-1789.2012.01352.x. Epub 2012 Oct 1.
Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3-5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from a nasal lesion. EBV expression in plasma cell neoplasms has been reported in very few cases that are mainly post-transplant or occurring in severely immunosuppressed patients. We report a case of extraosseous plasmacytoma with an aggressive course in an HIV-positive individual that occurred solely in the CNS, showing EBV expression by in situ hybridization, and presenting as an intraparenchymal mass as well as in the CSF.
骨外（髓外）浆细胞瘤是一种相对惰性的肿瘤，占所有浆细胞瘤的 3-5%。据报道，极少数病例确实发生在中枢神经系统，而不是从鼻腔病变扩展而来。在极少数主要发生在移植后或严重免疫抑制患者中的浆细胞瘤病例中，曾报道过 EBV 表达。我们报告了一例 HIV 阳性个体的骨外浆细胞瘤，其病程具有侵袭性，仅发生在中枢神经系统，原位杂交显示 EBV 表达，并表现为脑实质内肿块和脑脊液中均有病变。
