Parfitt Gustavo Morrone, Barbosa Ândrea Kraemer, Campos Renan Costa, Koth André Peres, Barros Daniela Martí
Laboratório de Neurociências, Instituto de Ciências Biológicas, Universidade Federal do rio Grande(FURG), Rio Grande, Brazil.
Behav Neurosci. 2012 Oct;126(5):729-34. doi: 10.1037/a0029861.
Memory persistence in the inhibitory avoidance (IA) task has been recently shown to require a new event of consolidation 12 hr after acquisition. The immobilization stress (IS) model is largely used to study the effects of stress on memory. In this study we investigated the interactions between stress by immobilization and its effect on the persistence of memory, and also a possible effect mediated by β-adrenergic modulation of stress on memory persistence. An enhancement of long-term memory (LTM) persistence caused by stress through immobilization applied 12 hr after IA training was observed when the animals were submitted to 15 min or 1 hr of IS, but not to 3 hr. The reversal of this memory enhancement caused by IS was observed when the β-adrenergic antagonist propranolol was infused intraperitoneally prior to stress, which implies that β-adrenergic receptors are involved in stress enhancement of LTM persistence.
最近研究表明，抑制性回避（IA）任务中的记忆持久性需要在习得后12小时发生一次新的巩固事件。固定应激（IS）模型主要用于研究应激对记忆的影响。在本研究中，我们调查了固定应激及其对记忆持久性的影响之间的相互作用，以及β-肾上腺素能对应激的调节作用对记忆持久性可能产生的影响。当动物接受15分钟或1小时的IS，但不是3小时时，观察到在IA训练后12小时施加的固定应激导致长期记忆（LTM）持久性增强。当在应激前腹腔注射β-肾上腺素能拮抗剂普萘洛尔时，观察到IS引起的这种记忆增强的逆转，这意味着β-肾上腺素能受体参与了LTM持久性的应激增强。
