Mater Children's Hospital, Raymond Terrace, South Brisbane, Queensland, Australia.
Pediatrics. 2012 Nov;130(5):e1243-51. doi: 10.1542/peds.2010-3517. Epub 2012 Oct 1.
To determine whether maternal report of infant behavioral dysregulation at 6 months is associated with a higher prevalence of behavioral concerns at 5, 14, and 21 years of age; and to assess the extent to which maternal and social factors may affect reported child behavior outcomes.
From the Mater-University of Queensland Study of Pregnancy cohort of 7223 live singleton babies, information on dysregulation was available for 6389 children at 6 months. Of those children, behavior data were available for 4836 at 5 years by using a modified Child Behavior Checklist, 4746 at 14 years by using a full Child Behavior Checklist and Youth Self-Report, and 3558 at 21 years by using a Young Adult Self-Report. Of the youth with dysregulation data at 6 months, 2308 completed the Composite International Diagnostic Interview at 21 years. Potential confounding and mediating factors were analyzed by using logistic regression.
Maternal-reported behavioral dysregulation at 6 months was associated with a significantly higher prevalence of maternal-reported behavior problems at 5 and 14 years (P < .001), but not youth self-reported problems at 14 or 21 years, or Composite International Diagnostic Interview-Diagnostic and Statistical Manual diagnoses at 21 years. The strength of association between infant dysregulation and maternal-reported behaviors was greater at 5 years than at 14 years, and was substantially reduced by adjusting for maternal, social, and infant factors, especially potentially the mediating factors of maternal anxiety and depression.
Infant behavioral dysregulation was a risk factor for maternal-reported behavior concerns at 5 and 14 years, although was unrelated to young adult mental health.
确定婴儿 6 个月时行为失调的母亲报告是否与 5 岁、14 岁和 21 岁时行为问题的更高患病率相关；并评估母亲和社会因素对报告的儿童行为结果的影响程度。
从昆士兰大学母婴研究的 7223 名活产单胎婴儿队列中，有 6389 名婴儿在 6 个月时可获得关于失调的信息。在这些儿童中，有 4836 名儿童在 5 岁时通过使用改良的儿童行为检查表获得了行为数据，4746 名儿童在 14 岁时通过使用完整的儿童行为检查表和青少年自我报告获得了行为数据，3558 名儿童在 21 岁时通过使用青少年自我报告获得了行为数据。在 6 个月时有失调数据的青少年中，有 2308 名在 21 岁时完成了综合国际诊断访谈。使用逻辑回归分析潜在的混杂和中介因素。
婴儿 6 个月时的行为失调母亲报告与 5 岁和 14 岁时母亲报告的行为问题明显更高的患病率相关（P<0.001），但与青少年自我报告的 14 岁或 21 岁的问题无关，也与 21 岁时综合国际诊断访谈-诊断和统计手册诊断无关。婴儿失调与母亲报告行为之间的关联强度在 5 岁时大于 14 岁，并且通过调整母亲、社会和婴儿因素，特别是潜在的中介因素（母亲焦虑和抑郁），该关联强度显著降低。
婴儿行为失调是 5 岁和 14 岁时母亲报告行为问题的危险因素，尽管与青年心理健康无关。
