Department of Agriculture, Nutrition and Veterinary Sciences, University of Nevada Reno, Reno, NV 89557, USA.
Cell Biochem Funct. 2012 Oct;30(7):531-51. doi: 10.1002/cbf.2842. Epub 2012 Jul 2.
Nuclear hormone receptors (NHRs), as ligand-dependent transcription factors, have emerged as important mediators in the control of whole body metabolism. Because of the promiscuous nature of several members of this superfamily that have been found to bind ligand with lower affinity than the classical steroid NHRs, they consequently display a broader ligand selectivity. This promiscuous nature has facilitated various bioactive dietary components being able to act as agonist ligands for certain members of the NHR superfamily. By binding to these NHRs, bioactive dietary components are able to mediate changes in various metabolic pathways, including, glucose, cholesterol and triglyceride homeostasis among others. This review will provide a general overview of the nuclear hormone receptors that have been shown to be activated by dietary components. The physiological consequences of such receptor activation by these dietary components will then be discussed in more detail.
核激素受体（NHRs）作为配体依赖性转录因子，已成为控制全身代谢的重要介质。由于这个超家族的几个成员具有与经典甾体 NHRs 相比亲和力较低的配体结合特性，因此它们表现出更广泛的配体选择性。这种混杂特性使得各种生物活性膳食成分能够作为某些 NHR 超家族成员的激动剂配体发挥作用。通过与这些 NHR 结合，生物活性膳食成分能够调节各种代谢途径的变化，包括葡萄糖、胆固醇和甘油三酯稳态等。本文将概述已被证实可被膳食成分激活的核激素受体，并更详细地讨论这些膳食成分对这些受体的激活所产生的生理后果。
