Paterson H F
J Embryol Exp Morphol. 1979 Aug;52:115-25.
The development of mouse embryos homozygous for oligosyndactylism (Os) is arrested during implantation. Histological investigations confirm a previous report that cells become blocked in mitosis, and air-dried spreads of the mutant embryos reveal that large numbers of cells accumulate in metaphase. Trophoblastic giant cells appear unaffected by the action of the mutant gene both in utero and during culture over the lethal phase. It is proposed that the form of endoreduplication undergone by giant cells renders them refractory to the metaphase block.
纯合少指（趾）畸形（Os）小鼠胚胎在着床期间发育停滞。组织学研究证实了之前的一份报告，即细胞在有丝分裂中受阻，突变胚胎的空气干燥涂片显示大量细胞积聚在中期。滋养层巨细胞在子宫内以及在致死期的培养过程中似乎不受突变基因作用的影响。有人提出，巨细胞经历的核内复制形式使它们对中期阻断具有抗性。
