Retina Division, Department of Ophthalmology, Wexner Medical Center at The Ohio State University, 915 Olentangy River Road, Suite 5000, Columbus, OH 43212, USA.
Mediators Inflamm. 2012;2012:936721. doi: 10.1155/2012/936721. Epub 2012 Sep 16.
Non infectious vitreous inflammation is often vision threatening and can be associated with potentially life-threatening systemic conditions. Treatment is often challenging as it involves systemic medications that can be associated with adverse effects. The classes of drugs are ever expanding and include corticosteroids, antimetabolites, alkylating agents, T-cell and calcineurin agents, biologic agents, and interferons. Each class of systemic therapy for non-infectious vitreous inflammation is reviewed. We discuss the mechanisms of action, usual clinical dosages, the specific conditions that are treated, the adverse effects, and usual course of treatment for each class of therapy.
非感染性玻璃体炎症常威胁视力，并可能与潜在危及生命的全身状况有关。治疗通常具有挑战性，因为它涉及可能产生不良反应的全身药物。药物类别不断扩大，包括皮质类固醇、抗代谢物、烷化剂、T 细胞和钙调神经磷酸酶制剂、生物制剂和干扰素。本文综述了非感染性玻璃体炎症的各种全身治疗方法。我们讨论了作用机制、常用临床剂量、治疗的具体情况、不良反应以及每种治疗方法的常用疗程。
