Nomura S, Osawa G
Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Clin Nephrol. 1990 Jan;33(1):7-11.
An open renal biopsy specimen from a twelve-year-old boy with a congenital solitary kidney was studied with light, electron, and fluorescent microscopy. Focal glomerular sclerotic lesions were disclosed by these microscopic examinations. Morphometric analysis revealed statistically significant hypertrophy of the glomeruli and significant reduction in the number of glomeruli when compared with controls of similar age. These findings suggested that not only the loss of one kidney, but also congenital reduction of nephrons contributed to the development of focal glomerular sclerotic lesions in this patient. There have been five reported cases of unilateral renal agenesis with oligomeganephronia in a solitary kidney [Van Acker et al. 1971, Griffel et al. 1972, Lam et al. 1982, Bhathena et al. 1985]. Our case, therefore, would be the sixth such case.
对一名患有先天性单肾的12岁男孩的开放性肾活检标本进行了光镜、电镜和荧光显微镜检查。这些显微镜检查发现了局灶性肾小球硬化病变。形态计量分析显示，与年龄相仿的对照组相比，肾小球有统计学意义的肥大，且肾小球数量显著减少。这些发现表明，不仅单肾的缺失，而且先天性肾单位减少都促成了该患者局灶性肾小球硬化病变的发展。已有5例关于单肾合并少巨肾单位的单侧肾缺如的报道[范·阿克等人，1971年；格里费尔等人，1972年；林等人，1982年；巴特纳等人，1985年]。因此，我们的病例将是第六例此类病例。
