Janků I, Modr Z, Krebs V
Institute of Pharmacology, Czechoslovak Academy of Sciences, Praha 2.
Int J Clin Pharmacol Ther Toxicol. 1990 Jan;28(1):27-32.
A set of graphical aids to drug dosage adjustment is presented, consisting of 1) a nomogram for evaluation of the dosage adjustment factor, 2) a nomogram for estimation of the creatinine clearance from the serum creatinine level, 3) decision tables for selection of a clinically acceptable adjustment of the dosing regimen. The set is accompanied by a list of percentage fractions excreted unchanged in urine for selected drugs and requiring adjustment of the dosing regimen in renal insufficiency. An example of the utilization of the set is demonstrated in comparison with the usual procedures of dosing regimen adjustment.
本文介绍了一套用于药物剂量调整的图形辅助工具，包括：1）用于评估剂量调整因子的列线图；2）用于根据血清肌酐水平估算肌酐清除率的列线图；3）用于选择临床上可接受的给药方案调整的决策表。该套工具还附有一份选定药物的尿中未变化排泄百分比分数列表，这些药物在肾功能不全时需要调整给药方案。通过与给药方案调整的常规程序进行比较，展示了该套工具的使用示例。
