Ding Chun-Li, Zhou Xue, Wang Bao-Jie, Ding Mei, Pang Hao
Key Laboratory of Evidence Identification in Universities of Shandong, Shandong University of Political Science and Law, Jinan 250014, China.
Fa Yi Xue Za Zhi. 2012 Aug;28(4):299-304.
Catechol-O-methyltransferase (COMT) gene encodes catechol-O-methyltransferase, the variant of this gene may affect the expression and metabolic activity of COMT. As the result of the changes of the effective concentration of the catecholamine neurotransmitter in the central nervous system, central nervous system dysfunctions associated with schizophrenia. This review summarizes genetic polymorphism and diversity of COMT gene. It also elaborates the relation between SNP and haplotype of COMT gene and three aspects, which including schizophrenia, attacking and violent tendency, and the frontal cognitive function of the schizophreniac. The correlativity study between genetic variation of the COMT gene and schizophrenia in patients with attacking and violent tendency may be helpful for the assessment of forensic psychiatry.
儿茶酚-O-甲基转移酶（COMT）基因编码儿茶酚-O-甲基转移酶，该基因的变体可能会影响COMT的表达和代谢活性。由于中枢神经系统中儿茶酚胺神经递质有效浓度的变化，会出现与精神分裂症相关的中枢神经系统功能障碍。本综述总结了COMT基因的遗传多态性和多样性。还阐述了COMT基因的单核苷酸多态性（SNP）与单倍型之间的关系以及三个方面，包括精神分裂症、攻击和暴力倾向以及精神分裂症患者的额叶认知功能。对有攻击和暴力倾向患者的COMT基因遗传变异与精神分裂症之间的相关性研究可能有助于法医精神病学的评估。
