Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Oral Dis. 2013 May;19(4):415-24. doi: 10.1111/odi.12022. Epub 2012 Oct 3.
The aim of this study is to characterize immunohistochemical profiles of lining epithelia of nasopalatine duct cyst (NPC) as well as to correlate those findings with their clinicopathological features to understand the histopathogenesis of NPC.
Forty-one surgical specimens from NPC were examined for clinical profiles and expression of keratin-7, 13, MUC-1, and P63 by immunohistochemistry, compared to radicular cyst (RC) and maxillary sinusitis.
Nasopalatine duct cyst was clinically characterized by male predominant occurrence: 44% of the cases involved tooth roots, and 70% with inflammatory backgrounds. Lining epithelia of NPCs without daughter cysts were immunohistochemically distinguished into three layers: a keratin 7-positive (+) ciliated cell layer in the surface, a keratin-13+ middle layer, and a MUC-1+/P63+ lower half, indicating that they were not respiratory epithelia, and the same layering pattern was observed in RC. However, those immunolocalization patterns of the main cyst lining with daughter cyst were exactly the same as those of daughter cyst linings as well as duct epithelia of mucous glands.
Two possible histopathogenesis of NPC were clarified: one was inflammatory cyst like RC and the other was salivary duct cyst-like mucocele.
本研究旨在描述鼻腭管囊肿（NPC）衬里上皮的免疫组织化学特征，并将这些发现与临床病理特征相关联，以了解 NPC 的组织发生。
对 41 例 NPC 手术标本进行临床特征和角蛋白 7、13、MUC-1 和 P63 的免疫组织化学表达检查，并与根尖囊肿（RC）和上颌窦炎进行比较。
鼻腭管囊肿的临床特征为男性发病为主：44%的病例涉及牙根，70%有炎症背景。无子囊的 NPC 衬里上皮通过免疫组织化学可分为三层：表面的角蛋白 7 阳性（+）纤毛细胞层、角蛋白 13+中间层和 MUC-1+/P63+下半层，表明它们不是呼吸上皮，RC 也观察到相同的分层模式。然而，主囊肿衬里的这些免疫定位模式与子囊衬里以及粘液腺的导管上皮完全相同。
明确了 NPC 的两种可能的组织发生机制：一种是类似于 RC 的炎症性囊肿，另一种是类似于唾液腺导管囊肿的黏液囊肿。
