INRS-Institut Armand-Frappier, University of Quebec, Laval, Canada.
Am J Epidemiol. 2012 Nov 1;176(9):751-9. doi: 10.1093/aje/kws318. Epub 2012 Oct 3.
Night work might influence cancer risk, possibly via suppression of melatonin release. In a population-based case-control study conducted in Montreal, Quebec, Canada, between 1979 and 1985, job histories, including work hours, were elicited from 3,137 males with incident cancer at one of 11 anatomic sites and from 512 controls. Compared with men who never worked at night, the adjusted odds ratios among men who ever worked at night were 1.76 (95% confidence interval (CI): 1.25, 2.47) for lung cancer, 2.03 (95% CI: 1.43, 2.89) for colon cancer, 1.74 (95% CI: 1.22, 2.49) for bladder cancer, 2.77 (95% CI: 1.96, 3.92) for prostate cancer, 2.09 (95% CI: 1.40, 3.14) for rectal cancer, 2.27 (95% CI: 1.24, 4.15) for pancreatic cancer, and 2.31 (95% CI: 1.48, 3.61) for non-Hodgkin's lymphoma. Equivocal evidence or no evidence was observed for cancers of the stomach (odds ratio (OR) = 1.34, 95% CI: 0.85, 2.10), kidney (OR = 1.42, 95% CI: 0.86, 2.35), and esophagus (OR = 1.51, 95% CI: 0.80, 2.84) and for melanoma (OR = 1.04, 95% CI: 0.49, 2.22). There was no evidence of increasing risk with increasing duration of night work, with risks generally being increased across all duration categories. Results suggest that night work may increase cancer risk at several sites among men.
夜班工作可能会影响癌症风险，这可能是通过抑制褪黑素的释放。在 1979 年至 1985 年期间，在加拿大魁北克省蒙特利尔市进行的一项基于人群的病例对照研究中，从 11 个解剖部位之一发生癌症的 3137 名男性和 512 名对照中获得了职业史，包括工作时间。与从未上过夜班的男性相比，曾经上过夜班的男性的肺癌、结肠癌、膀胱癌、前列腺癌、直肠癌、胰腺癌和非霍奇金淋巴瘤的调整比值比分别为 1.76（95%置信区间：1.25，2.47）、2.03（95%置信区间：1.43，2.89）、1.74（95%置信区间：1.22，2.49）、2.77（95%置信区间：1.96，3.92）、2.09（95%置信区间：1.40，3.14）、2.27（95%置信区间：1.24，4.15）和 2.31（95%置信区间：1.48，3.61）。对于胃癌（比值比（OR）=1.34，95%置信区间：0.85，2.10）、肾癌（OR=1.42，95%置信区间：0.86，2.35）和食管癌（OR=1.51，95%置信区间：0.80，2.84）和黑色素瘤（OR=1.04，95%置信区间：0.49，2.22），观察到的证据不确定或没有证据。没有证据表明随着夜班工作时间的延长，风险会增加，一般来说，所有工作时间类别都有增加的风险。结果表明，夜班工作可能会增加男性几个部位的癌症风险。
