Toyama Industrial Technology Center, 150 Futagami, Takaoka, Toyama 933-0981, Japan.
J Org Chem. 2012 Nov 2;77(21):9884-8. doi: 10.1021/jo301825j. Epub 2012 Oct 15.
Homoallylic alcohols were efficiently converted to the corresponding 3,4-epoxy alcohols in excellent yields by methyltrioxorhenium (MTO)-catalyzed epoxidation with aqueous hydrogen peroxide as the terminal oxidant and 3-methylpyrazole (10 mol %) as an additive. The epoxidations of homoallylic alcohols proceeded under organic solvent-free conditions faster than those in dichloromethane.
偕烯丙醇在三氧化铼-催化下，以双氧水为末端氧化剂，3-甲基吡唑（10mol%）为添加剂，高效转化为相应的 3,4-环氧醇，产率优异。在无溶剂条件下，偕烯丙醇的环氧化反应比在二氯甲烷中的反应速度更快。
