老年精神科患者使用丙戊酸相关的高血氨症。
Hyperammonemia associated with valproic acid use in elderly psychiatric patients.
机构信息
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2012 Summer;24(3):372-4. doi: 10.1176/appi.neuropsych.10100151.
Abstract
Valproic acid (VPA) is associated with hyperammonemia; however, little is known about this phenomenon in the geriatric psychiatric population. Of 12 such patients prescribed VPA, 83.3% had elevated ammonia. This occurred in the absence of elevated liver enzymes, and there was no association of VPA serum-level to hyperammonemia.
摘要
丙戊酸（VPA）与高血氨症有关；然而，关于老年精神病患者人群中这一现象知之甚少。在接受 VPA 治疗的 12 名此类患者中，83.3%的患者血氨升高。这种情况发生在肝酶没有升高的情况下，而且 VPA 血清水平与高血氨症之间没有关联。
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