受混合同种型Aβd/Eαd II类分子限制的抗原反应性T细胞克隆。
Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules.
作者信息
Matsunaga M, Seki K, Mineta T, Kimoto M
机构信息
Department of Immunology, Saga Medical School, Japan.
出版信息
J Exp Med. 1990 Feb 1;171(2):577-82. doi: 10.1084/jem.171.2.577.
Mixed isotype A beta dE alpha d class II molecule-restricted antigen-reactive T cell clones were obtained from (BALB/c x B6E alpha d)F1 mice. These T cell clones responded to keyhole limpet hemocyanin in the presence of (BALB/c x B6E alpha d)F1 but not CBF1 APCs. Both anti-A beta d and anti-E alpha mAbs blocked the proliferative responses of these clones. The frequency of such mixed isotype A beta E alpha-restricted T cell clones in (BALB/c x B6E alpha d)F1 mice was estimated to be approximately 10% from our limiting dilution cloning. The existence of such mixed isotype class II molecule-restricted T cells would have important implications for the expansion of the T cell repertoire as well as the induction of autoimmunity.
从（BALB/c×B6Eαd）F1小鼠中获得了混合同种型AβdEαdⅡ类分子限制性抗原反应性T细胞克隆。这些T细胞克隆在（BALB/c×B6Eαd）F1存在的情况下对钥孔戚血蓝蛋白有反应，但对CBF1抗原呈递细胞没有反应。抗Aβd和抗Eα单克隆抗体均阻断了这些克隆的增殖反应。通过有限稀释克隆法估计，（BALB/c×B6Eαd）F1小鼠中此类混合同种型AβEα限制性T细胞克隆的频率约为10%。此类混合同种型Ⅱ类分子限制性T细胞的存在对T细胞库的扩展以及自身免疫的诱导具有重要意义。
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