Division of Transfusion Medicine, Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Semin Thromb Hemost. 2012 Nov;38(8):839-44. doi: 10.1055/s-0032-1328886. Epub 2012 Oct 4.
Thrombotic microangiopathy is a pathological process that results in thrombocytopenia, schistocytes, and organ ischemia. A wide variety of causes of thrombotic microangiopathy have been described, each associated with a different pathological stimulus and predisposition toward certain vascular territories. This review will summarize our understanding of key drugs that have been classically and newly associated with thrombotic microangiopathy as well as mention of treatment options focusing on the role of plasma exchange.
血栓性微血管病是一种导致血小板减少、裂体细胞和器官缺血的病理过程。血栓性微血管病有多种原因，每种原因都与不同的病理刺激和某些血管区域的易感性有关。本文综述了我们对经典和新发现的与血栓性微血管病相关的关键药物的认识，并提到了以血浆置换为重点的治疗选择。
