Fritzsche K H, Neher P F, Reicht I, van Bruggen T, Goch C, Reisert M, Nolden M, Zelzer S, Meinzer H-P, Stieltjes B
German Cancer Research Centre, E 130 - Division of Medical and Biological Informatics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Methods Inf Med. 2012;51(5):441-8. doi: 10.3414/ME11-02-0031. Epub 2012 Sep 28.
Diffusion-MRI provides a unique window on brain anatomy and insights into aspects of tissue structure in living humans that could not be studied previously. There is a major effort in this rapidly evolving field of research to develop the algorithmic tools necessary to cope with the complexity of the datasets.
This work illustrates our strategy that encompasses the development of a modularized and open software tool for data processing, visualization and interactive exploration in diffusion imaging research and aims at reinforcing sustainable evaluation and progress in the field.
In this paper, the usability and capabilities of a new application and toolkit component of the Medical Imaging and Interaction Toolkit (MITK, www.mitk.org), MITK-DI, are demonstrated using in-vivo datasets.
MITK-DI provides a comprehensive software framework for high-performance data processing, analysis and interactive data exploration, which is designed in a modular, extensible fashion (using CTK) and in adherence to widely accepted coding standards (e.g. ITK, VTK). MITK-DI is available both as an open source software development toolkit and as a ready-to-use installable application.
The open source release of the modular MITK-DI tools will increase verifiability and comparability within the research community and will also be an important step towards bringing many of the current techniques towards clinical application.
扩散磁共振成像为研究活体人类的脑解剖结构以及此前无法研究的组织结构方面提供了一个独特的窗口。在这个快速发展的研究领域，人们正在大力开发应对数据集复杂性所需的算法工具。
本研究阐述了我们的策略，该策略包括开发一个模块化的开放软件工具，用于扩散成像研究中的数据处理、可视化和交互式探索，旨在加强该领域的可持续评估和进展。
本文使用活体数据集展示了医学成像与交互工具包（MITK，www.mitk.org）的一个新应用和工具包组件MITK-DI的可用性和功能。
MITK-DI提供了一个用于高性能数据处理、分析和交互式数据探索的综合软件框架，其设计采用模块化、可扩展的方式（使用CTK）并遵循广泛接受的编码标准（如ITK、VTK）。MITK-DI既可以作为开源软件开发工具包，也可以作为可直接安装使用的应用程序。
模块化的MITK-DI工具的开源发布将提高研究社区内的可验证性和可比性，也是朝着将许多当前技术推向临床应用迈出的重要一步。
